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John Robert Cardillo

John Robert Cardillo

John travelled the world to learn the best training and nutrition principles and trained alongside top pro bodybuilders at Gold's Gym California. He was a student of Arthur Jones, inventor of Nautilus and Medx Fitness machines, and the pioneer of hi-intensity training. John developed the HIT3 Training System, which transformed his physique to win countless bodybuilding competitions at just 18 years of age! He was also the first bodybuilder to utilize Faradic Electric Muscle Stimulation in his training and intermittent fasting during his competition prep. John’s SHREDDED Nutrition Diet helped him build one of the most shredded physiques of all time. His diet program incorporates fasting and nutrient timing to help athletes build lean muscle while losing body fat.

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Exercise and Its Effect on Aging By John Robert Cardillo

Dr. David Sinclair, a professor of genetics at Harvard Medical School, says that exercise is another way to combat the aging cycle. Sinclair has conducted experiments that demonstrate slowing and potential reversal of the aging cycle. He used an 80-year-old man as a test subject for his theory, and the man was confused for a much younger person based on his presentation.

Fasting and exercise slow or stop the aging clock because the body is forced to secrete chemicals that prevent chemical reactions that cause disease and health problems that reduce life expectancy. It’s the equivalent of stopping time for the molecular clock that drives the aging cycle. This extends life, and those who don’t engage in exercise and fasting experience mortality earlier than those who do.

Exercise, like fasting, is a terrific way to activate NAD+ to activate sirtuins in our cells. The reason for this reaction comes from the body’s response to the intensity of exercise. More intense exercise causes muscle cells to invigorate themselves to survive, leading to healthier cells.

Illness and Disease

The results of Sinclair’s experiments say that the body has a unique ability to ward off illness and disease when fasting and exercise are introduced in human activity. The chemical reaction created in the mitochondrial network is where it all starts. Mitochondria are the energy delivery system for the body and are flexible to meet the body’s needs. Working together, exercise and fasting create chemical reactions that keep the chemicals needed moving through the bloodstream.


Sinclair also takes metformin and says that it’s a relatively safe drug with only short-term side effects of gastrointestinal discomfort or diarrhea. Sinclair says that metformin works to help ward off the effects of aging in middle-aged people, and it’s a key ingredient for our bodies to prevent type 2 diabetes. Other conditions that metformin counteracts include heart disease, cancer, frailty, and Alzheimer’s.

Studies have shown that diabetics who take metformin live longer than non-diabetics who are otherwise healthy but don’t take metformin. In mammals and various organisms, life spans have been extended with its use.

Metformin acts on the liver by reducing the amount of glucose it releases into the bloodstream. It specifically makes our cells more sensitive to insulin, allowing more cellular glucose uptake by helping decrease insulin resistance. This results in lowering blood glucose levels. This occurs because metformin inhibits the function of mitochondria by causing minor damage to the cells, which in turn causes them to go into protect-and-repair mode. This causes the mitochondria to protect and repair themselves better.

The health benefits of exercise include the same mitochondrial damage occurring, which also forces them to repair better. Sinclair takes metformin only on days when he doesn’t exercise so that he doesn’t cause overly severe mitochondria stress on the exercise days.

The conclusions that have been drawn from the studies Sinclair presented detail that the miscommunication between the mitochondria and genomes cause age-related physiological decline. DNA breakdown in the aging cycle related to the relocalization of chromatin is a ground-breaking discovery.

Sinclair’s research has shown that the reprogramming of our molecular configuration will reset the aging cycle and increase life span. One thing about the molecular clock is that scientists aren’t in agreement about how many times it can be reset. With this newfound knowledge, Sinclair thinks that some diseases can be eradicated in the 21st century. Resetting the clock can be the way to stop cancer from infecting a healthy body due to humans aging more slowly than before.

As humans age, blood cells die. That causes reduced blood flow and oxygen deprivation to the systems that operate our bodies. Toxic buildup occurs because it isn’t rinsed through the body, which causes a breakdown of system operations. It creates a supply chain problem: Endothelial cells are the lining of blood vessels responsible for growth of blood cells that are the key transport agent for oxygen. When blood vessels die off, it reduces the body’s ability to develop new blood cells.

The loss of sirtuin function caused by the lack of endothelial cells is the direct result of deterioration of muscles and blood cells, which diminishes NAD+. NAD+ works as the tool kit for DNA and helps with repairs when threats have damaged the DNA. The human condition can be extended with exercise, fasting and taking resveratrol, NMN and metformin to extend human life. Taking supplements for extending life span is something Sinclair has demonstrated as effective in his many studies and written works.

For more on John Robert Cardillo, check out his website at johnrobertcardillo.com, his instagram at @johnrobertcardillo or right here at Muscle Insider at John Robert Cardillo.

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